Fighting circular DNA to prevent relapse in acute lymphoblastic leukaemia
Looking at whether medicines that prevent circular DNA replication can help prevent relapse.
Understanding how a new drug can selectively fight childhood cancer cells
Testing a new type of targeted treatment that applies to multiple types of childhood cancers.
Understanding how childhood cancers spread
Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.
Making an ‘off-the-shelf’ CAR-T cell treatment for children with solid cancers
Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.
How do immune cells protect childhood ependymoma tumours?
Looking at how brain tumours hijack immune cells, forcing them to support cancer growth instead of fighting it.
Rewriting cancer cell messages to slow down tumour growth
Testing medicines that can correct the genetic messages that help cancer cells grow out of control.
Predicting high-risk rhabdomyosarcoma at diagnosis to improve outcomes
Assessing rhabdomyosarcoma risk prediction markers based on the biological conditions in the tumour, like low oxygen levels, few blood vessels, and genetics.
Investigating the shape of fusion genes in rhabdomyosarcoma
How the 3D shape of fusion gene genetic code affects cancer cell behaviour and whether shape-modifying medicines could mitigate these effects.
Determining the best approach to treat children with relapsed anaplastic large cell lymphoma
Looking at why ALCL sometimes relapses with a new targeted treatment, and understanding how to optimise this treatment approach.