Our research projects

Dr Lucia Cottone at University College London hopes to understand how osteosarcoma cells become resistant to chemotherapy, which has a big impact on patient survival.

Dr Olivier Pardo at Imperial College London aims to find out how osteosarcoma cells survive the bloodstream and spread elsewhere in the body.

It is particularly difficult to treat some groups of childhood cancer patients, especially infants in their first weeks of life. This application is to fund this rapidly developing research programme for two years, involving the treatment of 150-200.

Evaluating a novel protein methyltransferase inhibitor for poor-prognosis rhabdomyosarcoma therapy

Diffuse midline glioma is a devastating brain tumour, affecting primarily young children. There’s currently no cure for this disease and treatment options are limited. This is mainly because this type of tumour is well-protected from drugs by the ‘blood-brain barrier’. This barrier physically blocks all medications from entering the brain. Our group has developed new methods of bypassing this barrier using focused ultrasound.

Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.

Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.

Looking at whether medicines that prevent circular DNA replication can help prevent relapse.

Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.