Could ‘prehabilitation’ help prepare children with cancer for a stem cell transplant?
Investigating whether diet or lifestyle changes could help children cope with bone marrow transplants better.
Studying the origins of childhood acute myeloid leukaemia to identify targets for kinder and more effective treatments
Learning more about leukaemia cells in order to design targeted treatments that can increase survivorship and quality of life.
Understanding CaMK1D in diffuse large B cell lymphoma in children
Understanding how a protein affects the growth and development of lymphoma cells in order to build the foundations for safer and more effective treatments.
Developing ways to identify chemotherapy resistant B-cell acute lymphoblastic leukaemia cells
Developing a test that can measure the amount of chemotherapy-resistant leukaemia cells in patient's blood samples. This would provide the foundations for future research.
Why does neurodegeneration occur in Langerhans cell histiocytosis?
Discovering what causes nerve cells to stop working and die years after a Langerhans cell histiocytosis diagnosis.
Exploring new targeted therapy options for acute myeloid leukaemia in babies
Looking for repurposed treatments that can fight leukaemia cells in very young children.
Understanding how Wilms tumour stem cells escape chemotherapy
Investigating cancer stem cells in Wilms tumour to see whether they are responsible for relapse, and to understand how that happens.
How does MYCN change the way genetic information is read?
Understanding how the MYCN protein changes the amounts of other proteins in the cell by changing the way DNA is processed and translated.
What happens in cells to make neuroblastoma develop and how can we stop this?
Looking at what extra pieces of chromosomes do in neuroblastoma and how these work with the MYCN protein to convert healthy cells into cancer cells.