Finding a cure for aggressive acute myeloid leukaemia in children
Professor Owen Williams hopes to develop a combination treatment with a revolutionary new drug that can more effectively fight acute myeloid leukaemia.
Discovering more about the development of childhood germ cell tumours
Dr Harry Leitch at Great Ormond Street Institute of Child Health will grow early reproductive cells in the lab to understand how germ cell tumours form and help develop new ways to test treatments.
Fine-tuning a new CAR T cell and drug combination for testing in solid childhood cancers
Professor John Anderson will test a new type of CAR T cell therapy designed to help children with solid cancers.
Using a DNA molecule as a new and safer treatment for neuroblastoma
Professor Arturo Sala will test a promising new adult cancer treatment in neuroblastoma to find a kinder and more effective treatment options.
Helping immunotherapy work better for children with neuroblastoma by reprogramming the tumour environment
Professor James Arnold is creating a new type of immunotherapy that can fight solid tumours and make it easier for the immune system to help.
Evaluation and optimization of drug combinations that kill neuroblastoma cancer cells
Professor Karim Malik aims to test a new combination of drugs that can eliminate neuroblastoma cells.
Finding kinder drugs in genetically matched cell models for childhood leukaemia
Professor Alex Thompson and his team at the University of Nottingham aim to learn more about leukaemia to support the development of kinder treatments.
Making CAR-T cells that can rest to improve their cancer-fighting ability
Professor John Anderson’s team at University College London Great Ormond Street Institute of Child Health aim to revolutionise CAR T-cell therapy for solid tumours.
Fighting brain cancer with CAR-T cells: Targeting zombie cells to improve therapy
Dr Ashley Vardon at the University of Birmingham hopes to find a way to effectively fight diffuse midline glioma with new immunotherapies.
Developing a new drug for the treatment of ALT-positive cancers
Dr Jon Elkins and Dr Anna Rose at the University of Oxford hope to develop a new drug which will affect vital ALT-positive cancer cell processes.
Degrading the anaplastic lymphoma kinase protein to treat paediatric cancers
Dr Lizzie Tucker will assess a new type of treatment to fight ALK-driven childhood cancers like neuroblastoma.
Investigating a new type of drug that can inhibit the growth and survival of neuroblastoma and other childhood cancers
Professor Karim Malik and Dr Jodie Bojko are testing drugs that can prevent cancer cells from making growth-promoting proteins.
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Our partnership supports hundreds of Little Princess Trust-funded projects, from developing new treatments to understanding the causes of cancer.