Little Princess Trust funded research

Dr Lucia Cottone at University College London hopes to understand how osteosarcoma cells become resistant to chemotherapy, which has a big impact on patient survival.

It is particularly difficult to treat some groups of childhood cancer patients, especially infants in their first weeks of life. This application is to fund this rapidly developing research programme for two years, involving the treatment of 150-200.

Looking at whether medicines that prevent circular DNA replication can help prevent relapse.

Testing a new type of targeted treatment that applies to multiple types of childhood cancers.

Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.

Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.

Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.

Testing medicines that can correct the genetic messages that help cancer cells grow out of control.

Looking at how brain tumours hijack immune cells, forcing them to support cancer growth instead of fighting it.

Developing a new dye to make kidney cancer surgery safer and more effective.

Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.

Investigating a protein found on leukaemia stem cells, the cells which cause relapse, and whether it could be a good drug target.