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Osteosarcoma bone cancer affects teenagers, around half of whom die within 5-years of diagnosis. We think we can solve these problems by modifying immune cells called “gamma-delta T-cells”.

Testing four medicines to see if they can shut down the metabolism of brain cancer cells grown in the lab

Finding which MEK inhibitors work best for children with acute myeloid leukaemia.

Testing whether treatment could be safely reduced for children with germinoma brain tumours

Ewing sarcoma is the second most common bone tumour in young people. The primary goal of this project is to fast-track a targeted drug combination for evaluation in clinical trials, with the aim of improving outcomes and minimising treatment associated morbidities for Ewing sarcoma patients.

Looking at the differences between healthy brain cells before and after treatment to uncover the mechanisms behind brain-related late effects.

Looking at a new subtype of leukaemia, called CML-like Ph+ALL, to see how best to diagnose and treat it.

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Using Burkitt lymphoma models to find essential survival genes to target for therapy.

Investigating a new theory for how kidney cancer grows and spreads.