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Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.

Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.

Looking at what extra pieces of chromosomes do in neuroblastoma and how these work with the MYCN protein to convert healthy cells into cancer cells.

Glo-BNHL trial is an international trial that will recruit children across the globe with relapse BNHL and assign them to the trial to receive a novel therapy. We are requesting funds to conduct biological studies alongside the trial to improve our understanding of this cancer.

Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.

Testing a new type of targeted treatment that applies to multiple types of childhood cancers.

Investigating cancer stem cells in Wilms tumour to see whether they are responsible for relapse, and to understand how that happens.

Immunotherapy could be a potential treatment for ependymoma. To make immunotherapy effective we need to know more about how ependymoma works.

Understanding how a repurposed drug attacks and kills diffuse midline glioma cells.

Acute lymphoblastic leukaemia (ALL) is a type of blood cancer. Around 400 children develop ALL in the UK each year.