Developing a kinder and more effective immunotherapy for neuroblastoma
Modifying current immunotherapy so that it doesn't cause damage to nerve cells and instead targets three molecules to help kill neuroblastoma cells more effectively.
Assessing a potent drug combination to fight Wilms tumour
Using two drugs to prevent an essential Wilms tumour protein interacting with a growth-promoting protein, and testing this treatment in patient samples.
Discovering what makes teenagers and young adults with soft tissue sarcomas different
Finding the biological differences between teenage and young adult cancers cells compared to older adults.
Identifying new treatment options for Burkitt lymphoma that doesn’t respond to treatment
Using Burkitt lymphoma models to find essential survival genes to target for therapy.
MonoGerm clinical trial – is one chemotherapy medicine safer for germinomas?
Testing whether treatment could be safely reduced for children with germinoma brain tumours
Understanding chemotherapy doesn’t work as well for some children with neuroblastoma
Investigating how cancer cells can keep dividing and why this makes it harder to treat.
Understanding how blood cancer develops and comes back after treatment in babies
Investigating how a protein changes the way leukaemia cells behave in babies.
Creating a new combination treatment for children's brain tumours
Repurposing medicines to support a new type of immunotherapy for brain tumours.
Finding out how infant leukaemia cells interact with the immune system
Understanding how leukaemia cells enlist immune system cells to help them survive chemotherapy.