Our research projects

Osteosarcoma bone cancer affects teenagers, around half of whom die within 5-years of diagnosis. We think we can solve these problems by modifying immune cells called “gamma-delta T-cells”.

This work focuses on defining how a new oncoprotein (called CARM1) we have discovered in neuroblastoma cells helps the cancer cells to survive, grow and avoid death.

Examining whether a group of drugs called gliflozins could be used to treat T-ALL

Developing and delivering small molecule drug and immunotherapy combinations for MYC-driven medulloblastoma: Efficacy, evolution and exploitation.

Repurposing antihistamines to reduce treatment-related toxicity for children with WNT-medulloblastoma

Investigating repurposed drugs to decrease the progression of Ewing’s sarcoma

Enhancing CAR T-cell expansion and prolonged persistence for the effective treatment of paediatric medulloblastoma

Drug repurposing targeting immunomodulatory Haem oxygenase-1 (HO-1) for prevention of osteosarcoma growth and metastasis

Evaluating the efficacy of Enhancer of Zeste Homolog 2 (EZH2) inhibitors in combination with anti-GD2/isotretinoin for the treatment of high-risk neuroblastoma: a pre-clinical study