Targeting childhood brain tumours from within: using a smart gel to deliver immunotherapy
Dr Karolina Dziemidowicz and her team at University College London aim to help CAR-T cells get to and fight an aggressive brain cancer.
Does radiotherapy make aggressive childhood brain tumours resistant to further treatment?
Dr Thomas Oliver at University College London will investigate whether the genetic changes caused by radiotherapy could make diffuse midline glioma tumours less responsive to other treatments.
Understanding how childhood medulloblastoma begins to identify new treatments
Dr Sarah Badodi at Queen Mary University of London will use new models to discover how and why medulloblastoma develops, identifying new ways to target the cancer.
Unlocking the potential of brain tumour MRI scans
Dr John Apps at the University of Birmingham will develop new AI tools to help doctors monitor childhood brain tumours throughout a child’s cancer journey.
Investigating how ependymoma uses proteins to spread through cerebrospinal fluid
Dr Timothy Ritzmann will investigate how proteins that regulate water inside the body could help ependymoma grow and spread.
Can we improve survival by changing frontline treatments for high-risk medulloblastoma?
Dr Rebecca Hill and her team hope to develop new tools to test chemotherapy options that will combine with radiotherapy to treat high-risk medulloblastoma.
Mapping connections with the brain in diffuse midline glioma
Professor Darren Hargrave aims to study electrical signals in the brain which could help diffuse midline glioma spread.
Discovering new blood-based signals for monitoring brain tumours in children
Dr Alina Pandele at the University of Nottingham hopes to find fragments cancer cell genetic code in the blood which can help doctors know when ependymoma grows back.
Looking for early signs on brain MRIs that can predict whether young people with ependymoma will go on to experience cognitive problems
Professor Shivaram Avula will identify markers in the brains of young people with brain tumours that will help predict the development of long-term side effects like learning and memory problems.