TPS and CDI

Idiopathic thickened pituitary stalk (iTPS) and/or idiopathic central diabetes insipidus (CDI)

Guideline for the investigation and management of Children and Young People aged up to 19 years

This guideline is intended to be a reference document for clinicians presented with the challenge of managing Children and Young People (CYP) up to the age of 19 years presenting with a Thickened Pituitary Stalk (TPS) and/or Central Diabetes Insipidus (CDI) where the aetiology is not apparent at presentation. Care of such patients differs in key aspects from that of adults, particularly in aetiology. This guideline seeks to identify and address these, in terms of presentation, clinical assessment, diagnosis, management, follow-up and prognosis of affected patients. Through robust literature searches and a Delphi consensus exercise, available scientific evidence and expert opinion has been brought together to produce a pragmatic set of decision making and management guidelines intended to optimise the quality of care of CYP with apparently idiopathic TPS and/or CDI, and form the basis for future audits of practice and outcomes.

Produced in association with the British Society for Paediatric Endocrinology and Diabetes and endorsed by the Royal College of Paediatrics and Child Health (RCPCH).

Full guideline 

Summary guideline