Could a medicine called ONC-201 help treat children with T-cell acute lymphoblastic leukaemia?
Looking at whether a pre-existing drug could be an effective and safe treatment due to its ability to target cancer cells directly.
Detecting lingering brain cancer cells before a tumour grows back
Ependymoma comes back after treatment around half of the time, because some cancer cells are still alive. If doctors could identify these cells and diagnose relapsed ependymoma sooner, children could start treatment earlier.
What role do small pieces of genetic code play in germ cell tumours?
Investigating how different levels short non-coding RNAs affect germ cell tumour cells, and testing whether medicines altering these levels could be a potential treatment.
What are the origins of liver cancer in children and why does treatment sometimes fail?
Understanding how hepatocellular carcinoma develops and what role the immune system plays.
Understanding how hospitals are offering chemotherapy infusions
Dr Jess Morgan at Leeds Children’s Hospital and Dr Gemma Bryan at University of Surrey hope to understand more about how hospitals are offering chemotherapy that needs to be given as infusions over a number of days.
Why does neurodegeneration occur in Langerhans cell histiocytosis?
Discovering what causes nerve cells to stop working and die years after a Langerhans cell histiocytosis diagnosis.
Exploring new targeted therapy options for acute myeloid leukaemia in babies
Looking for repurposed treatments that can fight leukaemia cells in very young children.
What happens in cells to make neuroblastoma develop and how can we stop this?
Looking at what extra pieces of chromosomes do in neuroblastoma and how these work with the MYCN protein to convert healthy cells into cancer cells.
Understanding how Wilms tumour stem cells escape chemotherapy
Investigating cancer stem cells in Wilms tumour to see whether they are responsible for relapse, and to understand how that happens.