How does MYCN change the way genetic information is read?
Understanding how the MYCN protein changes the amounts of other proteins in the cell by changing the way DNA is processed and translated.
Protecting young hearts from chemotherapy-related heart problems
Investigating whether giving a medicine before doxorubicin cancer treatment could prevent heart damage.
Investigating nanomedicines to make treatment safer for children with cancer
Looking at how nanoparticles could improve drug delivery and reduce toxicity for young cancer patients.
How does teenage and young adult cancer treatment affect the risk of kidney disease?
This project aims to find out more about kidney damage in teenagers and young adults who have been treated for cancer. Dr Nicola Hughes wants to know what puts young people with cancer at risk of kidney damage, and to create helpful information for patients and their families.
International clinical trial to test the use of dye during children’s cancer surgery
Testing whether a dye called Indocyanine Green (ICG) can help surgeons identify tumours and lymph nodes during surgery.
Exploring ‘Junk DNA’ to find undiscovered causes of cancer
Using a new way to measure genetic variation in key sections of noncoding DNA.
Investigating immune cells in sarcoma tumours
Finding why immunotherapy doesn't work for some children with sarcoma tumours.
Can radiotherapy near the spleen lead to severe infections later in life?
Looking into whether survivors of childhood cancer are at risk of severe infections.
New markers to select children with cancer for trials with PARP inhibitors
Novel biomarkers for PARP inhibitor trials for children with cancer