Understanding how childhood medulloblastoma begins to identify new treatments
Dr Sarah Badodi at Queen Mary University of London will use new models to discover how and why medulloblastoma develops, identifying new ways to target the cancer.
Investigating an immunotherapy combination treatment for neuroblastoma
Professors Suzanne Turner, Anna Philpott and Aditi Vedi at the University of Cambridge will test a new combination treatment for neuroblastoma that could make current immunotherapies more effective.
Unlocking the potential of brain tumour MRI scans
Dr John Apps at the University of Birmingham will develop new AI tools to help doctors monitor childhood brain tumours throughout a child’s cancer journey.
Targeting childhood brain tumours from within: using a smart gel to deliver immunotherapy
Dr Karolina Dziemidowicz and her team at University College London aim to help CAR-T cells get to and fight an aggressive brain cancer.
Using DNA damage to target osteosarcoma
Professor Sophie Postel-Vinay and Dr Lucia Cottone at University College London will look at whether osteosarcoma cells need a molecule called M1 to survive damage to their DNA.
Activating a protein to make immunotherapy more effective for neuroblastoma
Professor Aymen Al-Shamkhani at the University of Southampton hopes to test a way to recruit immune cells into neuroblastoma tumours, making immunotherapy more effective.
Does radiotherapy make aggressive childhood brain tumours resistant to further treatment?
Dr Thomas Oliver at University College London will investigate whether the genetic changes caused by radiotherapy could make diffuse midline glioma tumours less responsive to other treatments.
Using RNA to alter the metabolism in acute myeloid leukaemia cells
Dr Carmela De Santo at the University of Birmingham hopes to find a way to protect immune cells from acute myeloid leukaemia, so that they can fight the cancer.
PRECISION‑CSF: A new test to help personalise treatment for children with leukaemia
Professor Christina Halsey at the University of Glasgow hopes to improve testing of leukaemia cells around the brain, helping children receive the right amount of treatment.
Investigating how ependymoma uses proteins to spread through cerebrospinal fluid
Dr Timothy Ritzmann will investigate how proteins that regulate water inside the body could help ependymoma grow and spread.
Can we improve survival by changing frontline treatments for high-risk medulloblastoma?
Dr Rebecca Hill and her team hope to develop new tools to test chemotherapy options that will combine with radiotherapy to treat high-risk medulloblastoma.
Mapping connections with the brain in diffuse midline glioma
Professor Darren Hargrave aims to study electrical signals in the brain which could help diffuse midline glioma spread.