Published Trial Summaries
When trials have been completed and analysed, the results are written up and submitted to medical journals for publication so that the findings are disseminated to the rest of the medical community. These summaries are of trials which have been completed and the results published.
These easy-to-read public information summaries are prepared in collaboration with the CCLG Patient Advocacy Committee.
13-cis-retinoic acid (PK 2000 08)An investigation into the amount of the drug 13-cis-retinoic acid that is in a patient's bloodstream when given as capsules or mixed with food in children with high-risk neuroblastoma. More simply: Looking to see how much of the drug 13-cis-retinoic acid is in the bloodstream of patients during 14 days of treatment when taken or mixed with food or alone as a capsule.
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17q gain in neuroblastomaMeasuring genetic changes inside cancer cells can identify individual neuroblastoma patients at high risk of poor survival. More simply: Doctors and scientists now have a way to find out which patients with neuroblastoma have the most serious and aggressive cancer that needs the most specialised treatment.
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ALL 97 and ALL 97/99: Study to compare 6-thioguanine with 6-mercaptopurineA randomised study to assess the toxicity and efficiancy of 6-thioguanine (6-TG) and 6-mercaptopurine (6-MP) in children with acute lymphoblastic leukaemia (ALL). More Simply: Results from the comparison of the effectiveness and side-effects of 6-TG (6-Thioguanine) and 6-MP (6-Mercaptopurine) in children with ALL (acute lymphoblastic leukaemia).
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European Neuroblastoma Group Fifth Study (ENSG5)Randomised trial of high-dose rapid and standard induction chemotherapy for patients aged over 1 with stage 4 neuroblastoma. More simply: Looking at whether a more intensive programme of induction chemotherapy can improve survival. |
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Hepatoblastoma study (SIOPEL 1)Study comparing survival and response to treatment in children with different disease characteristics before treatment. More simply: Factors that predict the chance of survival and response to treatment. |
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Hepatoblastoma study (SIOPEL 2)Treatment for hepatoblastoma in children, adapted according to risk of treatment failure. More simply: Trial of tailored treatment for hepatoblastoma. |
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Interfant-99Observational study and multicentre, randomised trial in infants younger than 1 year with acute lymphoblastic leukaemia. More simply: Looking at whether a new protocol can improve survival in infants with acute lymphoblastic leukaemia. |
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International Society of Paediatric Oncology - Malignant Mesenchymal Tumor 89 (SIOP - MMT89)Results of the third study of the International Society of Paediatric Oncology into the treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence. More Simply: Results from treating children and teenagers with localised (for example, in the head, neck, limb, bladder or prostate) rhabdomyosarcoma, a form of soft tissue cancer |
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Phase I study of nolaxtrexed (AG337)A phase I study of nolatrexed dihydrochloride (AG337), in children with advanced cancer. A United Kingdom Children's Cancer Study Group Investigation. More simply: Results from treating children with cancer with nolatrexed |
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Primary postoperative chemotherapy (CNS 9204)Study of children with ependymoma, a type of brain tumour treated after surgery with chemotherapy instead of radiotherapy More simply: Looking at treating children with a type of brain tumour with chemotherapy, instead of using radiotherapy, after surgical removal of the tumour. |
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Primitive Neuroectodermal Tumour Study (PNET3)Comparison of chemotherapy followed by radiotherapy to just radiotherapy alone for the treatment of medulloblastoma, a tumour which arises in the cerebellum, located near the base of the brain. The cerebellum is responsible for balance and co-ordination. More simply: Does using chemotherapy before radiotherapy improve survival in children with medulloblastoma? |
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Study of Hodgkin's Lymphoma Patients Aged 5 Years and Under (HD1 and HD2)A retrospective analysis of results from a specific subgroup of Hodgkin’s Lymphoma patients, aged 5 years or younger, on the United Kingdom Children’s Cancer Study Group (UKCCSG) HD1 and HD2 trials. More simply: Looking specifically at results from Hodgkin’s Lymphoma patients, aged 5 years or younger, who were enrolled on two UKCCSG (now CCLG) clinical trials, identified as HD1 and HD2. |
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The second germ cell tumour study from the UKCCSG (GC-2)The combination of carboplatin, etoposide and bleomycin is an effective treatment for germ cell tumours in children with a low risk of serious side effects. More simply: For those children with germ cell tumours who need chemotherapy, there is a highly effective chemotherapy treatment with few serious side effects. |
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Wilms' Tumour Study 9101 (UKW3)Trial of preoperative chemotherapy in biopsy proven Wilms’ tumour versus immediate nephrectomy. More simply: Trial comparing the results of removing a kidney immediately, with the results of giving a course of chemotherapy first |
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